A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 49/06 (2006.01) A61K 49/10 (2006.01)
Patent
CA 2338702
Drugs for therapeutic use characterized by containing a compound which carries in its structure at least one member selected from among -17OH, -14NH and - 33SH, wherein the above 17O, 14N or 33S exerts a relaxation effect on the proton bonded thereto and the relaxation effect is transported through the exchange of a proton in a vital component of a target organ or tissue by the above-mentioned proton, thus enabling detection by nuclear magnetic resonance. The effective circulation or distribution of such a physiologically acceptable therapeutic drug in the target organ or tissue in vivo where it is needed can be externally detected by the nuclear magnetic resonance method before the administration of a remedy to each patient or simultaneously therewith.
La présente invention concerne des médicaments à vocation thérapeutique contenant un composé qui porte dans sa structure au moins un élément choisi parmi les -?17¿OH, -?14¿NH et -?33¿SH. En l'occurrence, les ?17¿O, ?14¿N ou ?33¿S ci-dessus exercent un effet de relaxation sur le proton qui y est lié, lequel effet de relaxation se propage par l'échange d'un proton dans un composant vital d'un organe ou tissu cible avec le proton déjà mentionné, ce qui permet la détection par RMN. La circulation ou la distribution d'un tel médicament thérapeutique physiologiquement acceptable in vivo dans l'organe ou le tissu cible peut être détectée par RMN avant l'administration d'un remède à chaque patient, ou simultanément à cette administration.
Fujimoto Chieko
Iwai Kumiko
Nakatani Akira
Seri Shigemi
Shimmura Toshiyuki
Marks & Clerk
Nihon Medi-Physics Co. Ltd.
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