A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/381 (2006.01) A61K 31/403 (2006.01) A61K 31/4164 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2743341
The present invention is directed to a compound for treatment or prevention of brain injury caused by diseases such as cerebrovascular disorder, brain degenerative disease and demyelinating disease and a method for screening the same. Brain injury in which prostaglandin D2 participates is treated or prevented by inhibition of hematopoietic prostaglandin D synthase induced in microglia cell or macrophage of a brain injury area by diseases such as cerebrovascular disorder, brain degenerative disease or demyelinating disease or by the inhibition of activation of prostaglandin D receptor expressed in astroglia cell around the injured area. The invention also provides a method of testing those pharmaceutical substances using a transgenic mouse in which human hematopoietic prostaglandin D synthase is expressed in large amounts.
Aritake Kosuke
Eguchi Naomi
Kadoyama Keiichi
Sato Yo
Taniike Masako
Japan Science And Technology Agency
Kirby Eades Gale Baker
LandOfFree
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