Drugs that enhance synaptic responses mediated by ampa...

Details Drugs that enhance synaptic responses mediated by ampa... Drugs that enhance synaptic responses mediated by ampa...

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/357 (2006.01) A61K 31/36 (2006.01) A61K 31/395 (2006.01) A61K 31/4015 (2006.01) A61K 31/443 (2006.01) A61K 31/4433 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2450801

This invention discloses compounds having the structure (see formula I) that are useful for enhancing synaptic responses mediated by AMPA receptors, methods for the preparation thereof, and methods for their use for treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number of excitatory synapses or in the number of AMPA receptors. The invention compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors and for improving memory encoding.

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