Drugs to improve synaptic transmission

Details Drugs to improve synaptic transmission Drugs to improve synaptic transmission

C - Chemistry, Metallurgy

07

D

C07D 313/00 (2006.01) A61K 31/365 (2006.01) A61K 31/395 (2006.01) A61K 31/557 (2006.01) C07D 225/04 (2006.01) C07D 225/06 (2006.01)

Patent

CA 2197673

Peripherally administered Brefeldin A and its analogs and derivatives are used to enhance learning and reverse memory dysfunction through induced long term potentiation in hippocampal tissues. Novel Brefeldin A analogs of the following structures are provided: (see formulas I to VIII) wherein each R is independently selected from -OH, OR1, -SH, -SR1, -NR2R2, and a carbonyl oxygen; each R' is independently a C1 to C4 alkyl; each R* is independently hydrogen or -OH; and wherein R1 is a C1 to C4 alkyl; and R2 is hydrogen or a C1 to C4 alkyl.

Brefeldine A et ses analogues et dérivés, administrés de manière périphérique pour stimuler le potentiel d'apprentissage et stopper les troubles de la mémoire grâce à une potentialisation induite à long terme dans les tissus hippocampiques.

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