C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/34 (2006.01) C12Q 1/25 (2006.01) G01N 33/52 (2006.01)
Patent
CA 2178048
A spectrophotometric assay for the detection of acetaminophen in aqueous fluids is carried out with a dry analytical element. The element comprises a support having thereon one or more reagent layers containing a first enzyme, aryl acylamidase, to cleave the amide bond of acetaminophen to produce p-aminophenol; and a mild oxidizing agent to oxidize the p-aminophenol so that it couples to a water-soluble coupling agent to form a dye that is read at 670 nm. The assay is precise, accurate on serum and plasma samples, and relatively free from significant interferences. The element also allows measurement over a broad dynamic range.
Arter Thomas C.
Mauck John C.
Schaeffer James R.
Winterkorn Robert F.
Gowling Lafleur Henderson Llp
Johnson & Johnson Clinical Diagnostics Inc.
Ortho-Clinical Diagnostics Inc.
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