Dry compositions

Details Dry compositions Dry compositions

A - Human Necessities

61

K

A61K 47/16 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/19 (2006.01) A61K 38/00 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 47/18 (2006.01) A61K 47/42 (2006.01) A61K 9/00 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2241179

The object of the present invention is to provide a dry composition having the following advantageous properties. That is, even when left in a highly humid environment, the dry composition of the present invention scarcely loses its pharmacological activity, does not deliquesce and retains its dry state over a long period of time. A dry composition of the present invention comprises at least one of active ingredients selected from the group consisting of pharmacologically active proteins and pharmacologically active polypeptides and as a stabilizer at least one of hydrophobic stabilizers selected from the group consisting of hydrophobic amino acids, hydrophobic dipeptides and hydrophobic tripeptides.

L'objet de la présente invention est de fournir une composition sèche ayant les caractéristiques avantageuses suivantes. C'est-à-dire que, même laissée dans un environnement très humide, la composition sèche de la présente invention ne perd presque pas son activité pharmacologique, ne tombe pas en déliquescence et retient son état sec pendant une longue période. Une composition sèche de la présente invention comprend au moins de ses ingrédients actifs sélectionnés parmi le groupe constitué de protéines pharmacologiquement actives et des polypeptides pharmacologiquement actifs et, comme stabilisant, au moins un stabiliant hydrophobe sélectionné parmi le groupe constitué des acides aminés hydrophobes, des dipeptides hydrophobes et des tripeptides hydrophobes.

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