Dry hemostatic compositions and methods for their preparation

A - Human Necessities – 61 – L

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Details

A61L 24/10 (2006.01) A61K 38/39 (2006.01) A61K 38/48 (2006.01) A61L 24/00 (2006.01) A61P 7/04 (2006.01)

Patent

CA 2453592

Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross- linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross- linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re- hydration medium, typically thrombin-containing saline.

Selon la présente invention, des compositions sèches de gélatine réticulée sont préparées. Lesdites compositions peuvent rapidement être réhydratées pour produire des hydrogels de gélatine pouvant servir d'adhésifs hémostatiques. La gélatine est réticulée en présence de certains supports de réhydratation, tels que le polyéthylène glycol, la polyvinylprovidone, et le dextran, de manière à produire une poudre sèche de gélatine réticulée. On a découvert que l'utilisation des supports de réhydratation augmente sensiblement le taux de réhydratation en présence d'un milieu de réhydratation aqueux, notamment de solution saline contenant de la thrombine.

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