Dry powder compositions having improved dispersivity

Details Dry powder compositions having improved dispersivity Dry powder compositions having improved dispersivity

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 9/14 (2006.01) A61K 9/19 (2006.01) A61K 9/72 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2389219

The present invention provides a highly dispersible formulation comprising an active agent and a dipeptide or tripeptide comprising at least two leucyl residues. The composition of the invention possesses superior aerosol properties and is thus preferred for aerosolized administration to the lung. Also provided are a method for (i) increasing the dispersibility of an active-agent containing formulation for administration to the lung, and (ii) delivery of the composition to the lungs of a subject.

La présente invention concerne une formulation hautement dispersable contenant un agent actif et un dipeptide ou un tripeptide comprenant au moins deux résidus leucyl. La composition de l'invention présente des propriétés aérosol supérieures et par conséquent on la préconise pour une administration en aérosol dans les poumons. En outre, cette invention concerne un procédé pour: (a) augmenter la dispersabilité d'une formulation contenant un agent actif pour l'administrer aux poumons, et (b) administrer la composition aux poumons du sujet.

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