Dry powder for inhalation

Details Dry powder for inhalation Dry powder for inhalation

A - Human Necessities

61

K

A61K 47/12 (2006.01) A61K 9/72 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2347856

The aim of the invention is to improve the moisture resistance of dry powder formulations for inhalation which contain a pharmaceutically not effective carrier of not-inhalable particle size and a finely divided pharmaceutical substance of inhalable particle size and to also improve the storage stability of said formulations. To this end, magnesium stearate is used in said formulations. One of the features of the inventive dry powder is that a high fine particle dosage or fine particle fraction can be maintained also under relatively extreme temperature and humidity conditions.

Selon l'invention, grâce à l'utilisation de stéarate de magnésium dans des compositions de poudres sèches pour inhalation qui contiennent un véhicule pharmaceutiquement non actif, sous la forme de particules d'une grandeur telle qu'elles ne peuvent pas être inhalées, ainsi qu'un principe actif pharmaceutique finement dispersé, sous la forme de particules d'une grandeur telle qu'elles peuvent être inhalées, on augmente la résistance à l'humidité desdites compositions et, en conséquence, leur stabilité au stockage, et l'on peut maintenir une dose ou une fraction élevée de particules fines, même dans des conditions de température et d'humidité relativement extrêmes.

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