Dry powder formulations of polynucleotide complexes

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/87 (2006.01) A61K 9/12 (2006.01) A61K 9/127 (2006.01) A61K 9/19 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 47/26 (2006.01) A61K 47/44 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2224156

Polynucleotide complexes are stabilized by adding a cryoprotectant compound and lyophilizing the resulting formulation, The lyophilized formulations are milled or sieved into a dry powder formulation which may be used to deliver the polynucleotide complex. Delivery of the polynucleotide to a desired cell tissue is accomplished by contacting the tissue with the powder to rehydrate it. In a preferred embodiment, a dry powder formulation is used to induce genetic modification of a patient's lung tissue.

On stabilise des complexes polynucléotidiques par adjonction d'un composé cryoprotecteur et lyophilisation de la formulation obtenue. On utilise ces formulations lyophilisées, après les avoir moulues en une poudre sèche ou les avoir tamisées, pour administrer le complexe polynucléotidique. Cette administration se fait par la mise en contact de la poudre avec le tissu afin de réhydrater celui-ci. Dans un mode de réalisation préféré, on emploie cette formulation en poudre sèche pour déclencher une modification d'ordre génétique dans le tissu pulmonaire d'un patient.

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