Dry reagent delivery system

G - Physics – 01 – N

Patent

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150/1, 150/8, 15

G01N 33/52 (2006.01) G01N 33/53 (2006.01) G01N 33/62 (2006.01) G01N 33/66 (2006.01) G01N 33/92 (2006.01)

Patent

CA 1317532

ABSTRACT A method for the preparation of a dry chemistry reagent system suitable for analysis of heterogenous fluid samples, the method comprising: providing a bibulous film having an essentially uniform composition, the film being characterized as having two planar surfaces and a porosity gradient from one planar surface to the other, the inherent porosity on at least one of the planar surfaces being essentially exclusive of particular matter on the order of magnitude of cells present in biological fluid samples; sequentially imbibing into said film (i) an indicator and (ii) a reagent cocktail specific for reaction with an analyte believed to be present in the fluid sample; and contacting the bibulous film with an absorption effective amount of conditioning agent, the conditioning agent enhancing the absorption characteristics of the film to fluid samples, the contact of the film with a conditioning agent occurring either independent o f and prior in time to contact of the film with an indicator or subsequent to contact of the film with the indicator.

557423

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