C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 15/11 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2377135
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-10, and polypeptide variants thereof that stimulate dephosphorylation of DSP-10 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-10 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
La présente invention concerne des compositions et des méthodes de traitement des états associés à la prolifération cellulaire, à la différentiation cellulaire, et à la durée de vie des cellules. Cette invention concerne particulièrement le phosphatase DSP-10 à double spécificité et ses variants de polypeptide qui stimulent la déphosphorylation des substrats DSP-10. En outre, on peut utiliser ces polypeptides par exemple pour identifier les anticorps et autres agents inhibant l'activité du DSP-10. De plus, on peut utiliser ces polypeptides et agents pour moduler la prolifération, la différenciation et la durée de vie des cellules.
Luche Ralf M.
Wei Bo
Ceptyr Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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