Dsp-18 dual-specificity phosphatase

Details Dsp-18 dual-specificity phosphatase Dsp-18 dual-specificity phosphatase

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12P 19/34 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2447583

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and/or cell survival. In particular, the dual-specificity phosphatase DSP-18 isoforms DSP-18a-f, and polypeptide variants thereof that stimulate dephosphorylation of DSP-18 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-18 activity. The polypeptides and agents may be used to modulate cell proliferation, cell differentiation and cell survival.

L'invention concerne des compositions et des méthodes de traitement des états pathologiques associés à la prolifération cellulaire, à la différenciation cellulaire et/ou à la survie cellulaire. L'invention concerne en particulier les isoformes DSP-18a-f de la phosphatase DSP-18 à double spécificité, et leurs variants polypeptidiques stimulant la déphosphorylation de substrats de la DSP-18. Les polypeptides peuvent être utilisés, par exemple, pour identifier des anticorps et d'autres agents inhibant l'activité de la DSP-18. Les polypeptides et les agents peuvent être utilisés pour moduler la prolifération cellulaire, la différenciation cellulaire et la survie cellulaire.

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