Dsrna compositions and methods for treating hpv infection

Details Dsrna compositions and methods for treating hpv infection Dsrna compositions and methods for treating hpv infection

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61P 31/20 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2644621

The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from among HPV E1, HPV E6 and the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.

L'invention concerne un acide ribonucléique double brin (ARNdb) destiné au traitement d'une infection par le papillomavirus humain (HPV). L'ARNdb comprend un brin antisens ayant une séquence nucléotidique qui fait moins de 30 nucléotides de long, en général 19 à 25 nucléotides de long, et qui est sensiblement complémentaire à au moins une partie d'un gène cible d'HPV choisi parmi HPV E1, HPV E6 et le gène E6AP humain. L'invention concerne également une composition pharmaceutique comprenant l'ARNdb conjointement avec un support pharmaceutiquement acceptable ; des procédés permettant de traiter des maladies provoquées par une infection par l'HPV et l'expression du gène E6AP à l'aide de la composition pharmaceutique ; et des procédés permettant d'inhiber l'expression des gènes cibles d'HPV dans une cellule.

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