Dtf-a gene, diagnostic and therapeutic uses thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2271326

The present invention relates to the novel therapeutic use of a gene regulated by FOS and RAS transforming pathways, which is identified as dft-A, and which comprises the sequence set forth in Fig. 3. There is also disclosed the novel use of a dft-A protein and an antibody recognizing same. The present invention also relates to a diagnostic method of identifying dft-A mutations in cancer or other diseases in a biological sample of a patient, which comprises: a) subjecting DNA present in the patient's sample to gene sequencing; and b) comparing the sequenced DNA with the sequence of dft-A gene to identify dft-A mutations. The present invention also relates to a diagnostic method of identifying change in dft-A protein level in cancer or other diseases in a biological sample of a patient, which comprises: a)subjecting the patient's sample to the anti-dft-A antibody to form an antibody-dft-A protein complex; and b) detecting the antibody-dft-A protein complex to determine the dft-A protein level in the biological sample.

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