C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/261, 167/267
C07C 229/26 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 49/06 (2006.01) C07C 237/04 (2006.01) C07C 237/12 (2006.01) C07F 5/00 (2006.01) C07F 15/02 (2006.01)
Patent
CA 2039846
Abstract Compounds of general formula I Image (I) in which Z1 and Z2 each stand for a hydrogen atom or the radical Image in which m and n independently mean numbers 0-20, k, l, q and r independently mean numbers 0 and 1 and R means a hydrogen atom, an optionally OR1-substituted C1-C6 alkyl radical or a CH2COOR1 group with R1 meaning a hydrogen atom, a C1-C6 alkyl radical or a benzyl group, R2 stands for a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C atoms, an aryl group or aralkyl group, all substituted by a carboxyl group or a sulfide group, each optionally esterified with a C1-C6 alkyl radical or benzyl radical, R3 stands for a hydrogen atom or for a saturated, unsaturated, straight-chain or branched-chain or cyclic non- aromatic hydrocarbyl group with up to 20 C atoms, an aryl group or aralkyl group, in each case being optionally substituted by a carboxyl group or a sulfone group, each optionally esterified with a C1-C6 alkyl radical or benzyl radical, X stands for a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, provided that at least one of substituents Z1 and Z2 stands for a hydrogen atom, that -- if n and 1 each stand for the number O -- k and r are not the number 1 at the same time and that the radical of the acid groups is optionally present as an ester or amide as well as their salts with inorganic and/or organic base, amino acids or amino acid amides, are valuable pharmaceutical agents.
Conrad Jurgen
Gries Heinz
Klieger Erich
Raduchel Bernd
Schmitt-Willich Heribert
Marks & Clerk
Schering Aktiengesellschaft
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