C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/66 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/4412 (2006.01) A61P 9/00 (2006.01) C07D 213/64 (2006.01) C07D 231/14 (2006.01) C07D 233/64 (2006.01) C07D 233/68 (2006.01) C07D 233/70 (2006.01) C07D 233/90 (2006.01) C07D 249/08 (2006.01) C07D 403/10 (2006.01)
Patent
CA 2682508
The invention is directed to compounds having the formula: (I) wherein: Ar, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
La présente invention concerne : des composés de formule (I) dans laquelle Ar, r, Y, Z, Q, W, X et R5-7 sont tels que définis dans la description ; ainsi que leurs sels acceptables d'un point de vue pharmaceutique. Ces composés possèdent une activité antagoniste du récepteur AT1 et une activité d'inhibition de la néprilysine. Cette invention a trait également : aux compositions pharmaceutiques contenant ces composés ; aux procédés d'utilisation de ces composés ; ainsi qu'aux procédés et intermédiaires utiles dans la préparation de ces composés.
Allegretti Paul
Choi Seok-Ki
Fatheree Paul R.
Gendron Roland
Jendza Keith
Theravance Inc.
Torys Llp
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