Dual-acting benzoimidazole derivatives and their use as...

Details Dual-acting benzoimidazole derivatives and their use as... Dual-acting benzoimidazole derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 235/08 (2006.01) A61K 31/4184 (2006.01) A61P 9/00 (2006.01) C07D 235/26 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2705921

The invention relates to compounds having the formula: (I) wherein Ar, r, n, X, R2, R2, R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.

L'invention concerne des composés de formule : (I) où AR, r, n, X, R2, R2', R3, et R5-7 sont tels que définis dans la description, ou un sel acceptable du point de vue pharmaceutique de ceux-ci. Ces composés ont une activité antagoniste de récepteur AT1 et une activité d'inhibition de néprilysine. L'invention concerne également des compositions pharmaceutiques comportant de tels composés ; des procédés d'utilisation de tels composés, ainsi qu'un procédé et des produits intermédiaires pour préparer de tels composés.

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