Dual action 2',5'-oligoadenylate antiviral derivatives and...

Details Dual action 2',5'-oligoadenylate antiviral derivatives and... Dual action 2',5'-oligoadenylate antiviral derivatives and...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07J 43/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2130926

Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2',5'-oligoadenylate (2-5A) de- rivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described:

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