Dual action anticancer prodrugs

Details Dual action anticancer prodrugs Dual action anticancer prodrugs

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) A61K 31/505 (2006.01) A61K 31/675 (2006.01) A61K 31/70 (2006.01) C07D 239/54 (2006.01) C07D 409/04 (2006.01) C07F 9/6512 (2006.01)

Patent

CA 2252144

This invention is concerned with novel dual acting anti-tumor drugs. These dual acting anti-tumor drugs comprise at least two moieties. One of the moieties can be an agent that stimulates the differentiation of tumor cells. Examples of the moiety includes butanoyl and retinoyl groups. Another moiety is a hydroxy-containing anti-tumor agent. Examples of the hydroxy-containing anti-tumor agent are nucleoside analogs, steroids having anti-tumor activity and anthracyclines. Also disclosed, are methods of using the dual acting anti-tumor drugs to prevent or treat a tumor and a process of making these drugs.

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