Dual-action tablet

Details Dual-action tablet Dual-action tablet

A - Human Necessities

61

K

167/164

A61K 47/30 (2006.01) A61K 9/24 (2006.01)

Patent

CA 2010037

The present invention provides a dual-action tablet composi- tion comprising: (a) an outer tablet comprising a first dose of active ingredient dispersed in a pH independent hydrophilic polymer matrix; and (b) an inner tablet comprising a second dose of active ingredient in a rapidly disintegrating excipient base. This dual-action tablet is especially efficacious for those active ingredients which have half lives of less than two hours and which experience decreased absorption efficiency in the lower gastrointestinal tract. Among the preferred dual-action tablet compositions is one wherein the active ingredient in both the inner and outer tablets is guaifenesin. Upon administration, the outer tablet provides a controlled release of the active ingredient while the inner tablet gives a second dose of active ingredient after the outer tablet has partially dissolved.

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