Dual avb3 and metastasis-associated receptor ligands

Details Dual avb3 and metastasis-associated receptor ligands Dual avb3 and metastasis-associated receptor ligands

C - Chemistry, Metallurgy

07

K

C07K 14/56 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) C07K 14/52 (2006.01) C07K 14/78 (2006.01) C07K 19/00 (2006.01) C12N 9/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2325342

The present invention relates to pharmaceutical compounds which are dual avb3 receptor/metastasis-associated receptor ligands. The use of these dual ligands alone or in conjunction with other agents in pharmaceutical compositions, and in methods for treating conditions mediated by avb3 for the treatment of cancer and other angiogenic diseases, such as diabetic retinopathy, arthritis, hemangiomas, and psoriasis, are also disclosed.

L'invention porte sur des composés pharmaceutiques ligands doubles du récepteur a¿v?b¿3? et du récepteur associé aux métastases, sur l'utilisation de ces ligands doubles, seuls ou en association avec d'autres agents, dans des préparations pharmaceutiques, et sur des méthodes de traitement d'états induits par l'a¿v?b¿3? et du cancer et d'autres maladies angiogènes telles que la rétinopathie diabétique, l'arthrite, les hémangiomes et le psoriasis.

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