Dual binding site acetylcholinesterase inhibitors for the...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01) A61K 31/473 (2006.01) A61P 25/00 (2006.01) C07D 219/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2501491

A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile dementia, cerebrovascular dementia, mild cognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimer~s disease, Parkinson disease, ALS, or prion diseases, as Creutzfeldt-Jakob disease or Gerstmann-Straussler-Scheinher disease.

L'invention concerne une famille de composés représentée par la formule (I). Dans cette formule, X représente les radicaux suivants : (a),(b) ou (c) qui agissent en tant qu'inhibiteurs d'acétylcholinestérase à site double et qui sont particulièrement utiles dans le traitement de troubles cognitifs tels que la démence sénile, la démence cérébrovasculaire, les déficiences cognitives légères, le trouble déficitaire de l'attention, et/ou les maladies démentielles neurodégénératives à agrégations protéiques aberrantes telles que notamment la maladie d'Alzheimer, la maladie de Parkinson, la sclérose latérale amyotrophique (SLA), ou les maladies à prion, telles que la maladie de Creutzfeldt-Jakob ou la maladie Gerstmann-Straussler-Scheinher.

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