Dual drug dosage forms with improved separation of drugs

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/22 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2531721

Drug tablets that include a prolonged-release core and an immediate-release layer or shell are prepared with a thin barrier layer of drug-free polymer between the prolonged-release and immediate-release portions of the tablet. The barrier layer is penetrable by gastrointestinal fluid, thereby providing full access of the gastrointestinal fluid to the prolonged-release core, but remains intact during the application of the immediate-release layer, substantially reducing or eliminating any penetration of the immediate-release drug into the prolonged-release portion.

L'invention concerne des comprimés médicamenteux qui comprennent un noyau à libération prolongé et une couche ou une coquille à libération immédiate. Ces comprimés présentent une couche barrière mince, constituée d'un polymère exempt de médicaments, qui est placée entre la couche à libération prolongée et la couche à libération immédiate. La couche barrière peut être pénétrée par le flux gastro-intestinal ce qui permet l'accès total du fluide gastro-intestinal au noyau à libération prolongée, mais elle reste intacte pendant l'application de la couche à libération immédiate, ce qui réduit ou empêche la pénétration du médicament à libération immédiate dans la partie à libération prolongée.

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