Dual fiber bioreactor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/02 (2006.01) C12M 3/02 (2006.01) C12M 3/06 (2006.01) C12N 5/06 (2006.01) A61M 1/34 (2006.01) A61M 1/36 (2006.01)

Patent

CA 2195767

A cell culture unit is disclosed herewith comprising a shell having two ends with an elongated chamber there between. A liquid and a gas perfusion port are located on each end. Liquid perfusion fibers are connected to the liquid perfusion ports and gas perfusion fibers are connectd to the gas perfusion ports. These fibers thereby define an extracapillary and intracapillary space. The cell culture unit further comprises means for communicating with the intracapillary space of the gas perfusion fibers, means for communicating with the intracapillary space of the liquid perfusion fibers, and means for communicating with the extracapillary space.

L'invention concerne une unité de culture de cellules, comprenant une enveloppe avec deux extrémités et une chambre allongée intermédiaire. Une ouverture de perfusion de liquides et une ouverture de perfusion de gaz sont ménagées à chaque extrémité. Des fibres de perfusion de liquides sont reliées aux ouvertures de perfusion de liquides et des fibres de perfusion de gaz sont reliées aux ouvertures de perfusion de gaz. Ces fibres définissent ainsi un espace extracapillaire et un espace intracapillaire. L'unité de culture de cellules comprend en outre des moyens de communication avec l'espace intracapillaire des fibres de perfusion de gaz, des moyens de communication avec l'espace intracapillaire des fibres de perfusion de liquides et des moyens de communication avec l'espace extracapillaire.

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