Dual inhibitors of pde 7 and pde 4

Details Dual inhibitors of pde 7 and pde 4 Dual inhibitors of pde 7 and pde 4

A - Human Necessities

61

K

A61K 31/52 (2006.01) A61K 31/00 (2006.01) A61K 31/505 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 473/16 (2006.01) C07D 487/04 (2006.01) C07D 491/10 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2444436

Dual inhibitors of PDE7 and PDE4, together with their use to treat leukocyte activation-associated disorders (including transplant rejection, rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma, chronic obstructive pulmonary disease, lupus and multiple sclerosis), are provided herein.

L'invention concerne des doubles inhibiteurs de la PDE7 et de la PDE4, ainsi que leur utilisation pour traiter les troubles associés à l'activation leucocytaire (tels que rejets de transplants, polyarthrite rhumatoïde, maladie intestinale inflammatoire, psoriasis, asthme, bronchopneumopathie chronique obstructive, lupus et sclérose en plaques).

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