Dual inhibitors of wax ester and cholesteryl ester synthesis...

Details Dual inhibitors of wax ester and cholesteryl ester synthesis... Dual inhibitors of wax ester and cholesteryl ester synthesis...

C - Chemistry, Metallurgy

07

C

C07C 311/52 (2006.01) A61K 31/00 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61K 31/27 (2006.01) A61K 31/325 (2006.01) A61K 31/64 (2006.01) C07C 307/02 (2006.01) C07C 311/50 (2006.01) C07C 311/51 (2006.01)

Patent

CA 2395006

The present invention provides a method of inhibiting sebum production and treating sebaceous gland disorders comprising administering to a patient in need of said treatment an effective amount of a compound that inhibits both acyl-Coenzyme A:cholesteryl acyltransferase (ACAT), and acyl-Coenzyme A:fatty alcohol acyltransferase (AFAT), provided that the compound is not [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diisopropyl- phenyl ester or a pharmaceutically acceptable salt or solvate thereof. The method of the invention is useful to treat sebaceous gland disorders caused or exacerbated by the overproduction of sebum, including oily skin, acne, seborrhea, perioral dermatitis, rosacea, and corticosteroid-induced acneiform lesions.

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