Dual mobile phase apparatus and method

B - Operations – Transporting – 01 – J

Patent

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Details

IPC codes

B01J 19/00 (2006.01)

Type

Patent

Patent number

CA 2748933

Description

An apparatus and system for contacting a mobile elongate solid phase, e.g. a ribbon with a flowing fluid phase, and a method for using the same in, for example solid phase synthesis. A particular apparatus comprises (i) a conduit which is of circular or non-circular transverse cross section and which defines a lumen to contain both the flowing fluid phase and the mobile elongate solid phase; (ii) fluid phase ports in communication with the lumen to allow the fluid phase to enter the lumen, flow through it and exit it; and (iii)solid phase ports in communication with the lumen to allow the mobile solid phase to enter the lumen, move through it and exit it, the apparatus being adapted to prevent fluid egress from its interior through the solid phase ports. Also provided is a continuous process for synthesising and screening molecules, comprising passing an elongate solid phase through successive treatment stations where different stages of a solid phase synthesis are performed, and screening the synthesised molecules for activity.

Dispositif et système permettant de mettre en contact une phase solide de forme étirée mobile tel qu'un ruban et une phase fluide en écoulement ainsi qu'un procédé d'utilisation correspondant, par exemple pour une synthèse en phase solide. Un dispositif particulier comprend (i) un conduit de section transversale circulaire ou non qui définit une lumière contenant à la fois la phase fluide en écoulement et la phase solide de forme étirée mobile ; (ii) des orifices pour phase fluide, communiquant avec la lumière, qui laissent la phase fluide pénétrer dans cette lumière, la traverser et la quitter ; et (iii) des orifices pour phase solide, communiquant avec la lumière, qui laisse la phase solide pénétrer dans la lumière, la traverser et la quitter. Le dispositif est conçu pour empêcher le fluide de sortir de l'intérieur par les orifices pour phase solide. L'invention concerne également un processus continu de synthèse et de criblage de molécules, qui consiste à faire passer une phase solide de frome étirée mobile par des postes de traitement successifs au cours dans lesquels se déroulent des étapes différentes de la synthèse en phase solide.

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