Dual modulators of 5-ht2a and d3 receptors

Details Dual modulators of 5-ht2a and d3 receptors Dual modulators of 5-ht2a and d3 receptors

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/454 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2694009

The present invention relates to compounds of the general formula (I), wherein R1, R2, X and n are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.

La présente invention porte sur des composés représentés par la formule générale (I) dans laquelle R1, R2, X et n sont tels que définis dans la description en tant que modulateurs doubles des récepteurs de la sérotonine 5-HT2a et de la dopamine D3, sur leur fabrication, sur des compositions pharmaceutiques les contenant, et sur leur utilisation comme médicaments. Les composés de la formule générale (I) ont une haute affinité pour les récepteurs de la dopamine et 5-HT2a de la sérotonine (5-Hydroxytryptamine ; 5-HT) et sont efficaces dans le traitement de troubles psychotiques, ainsi que d'autres maladies telles que la dépression et l'anxiété, la dépendance vis-à-vis des médicaments, les démences et la défaillance de mémoire.

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