C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/4709 (2006.01) A61P 33/06 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2405076
The invention concerns dual molecules formed by coupling products with a molecule residue exhibiting antimalarial activity, 1 or 2 C¿1?-C¿5? alkylene chains comprising an amine, amide, sulphonamide, carboxyl, ether or thioether function providing the bond between the two chains, a polycyclic structure linked to a cyclic peroxide of 4 to 8 members, and their addition salts with pharmacologically acceptable acids. The invention is useful as medicines with antimalarial activity.
L'invention vise des molécules duales formées de produits de couplage avec un résidu de molécule à activité antipaludique, 1 ou 2 chaînes alkylène en C1 à C5, comportant une fonction amine, amide, sulfonamide, carboxyle, éther ou thioéther, assurant le lien entre les 2 chaînes, une structure polycyclique reliée à un peroxyde cyclique de 4 à 8 chaînons, et leurs sels d'addition avec des acides pharmacologiquement acceptables. Application en tant que médicaments à activité antipaludique.
Benoit-Vical Francoise
Dechy-Cabaret Odile
Meunier Bernard
Robert Anne
Centre National de La Recherche Scientifique (c.n.r.s.)
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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