C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/551 (2006.01) A61P 11/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2714419
The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of/ and or prophylaxis of respiratory diseases, including antiinflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.
La présente invention concerne de nouveaux composés représentés par la formule (I), des compositions pharmaceutiques et leur utilisation thérapeutique, par exemple comme inhibiteurs de la phosphodiestérase de type IV (PDE4) et comme antagonistes des récepteurs d'acétylcholine muscariniques (mAChR), dans le traitement et/ou la prophylaxie de maladies respiratoires, notamment des maladies inflammatoires et/ou allegiques telles que la maladie pulmonaire obstructive chronique (MPOC), l'asthme, la rhinite (par exemple la rhinite allergique), la dermatite atopique ou le psoriasis.,
Callahan James Francis
Lin Guoliang
Wan Zehong
Yan Hongxing
Glaxo Group Limited
Gowling Lafleur Henderson Llp
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