Dual recombinant gene therapy compositions and methods of use

Details Dual recombinant gene therapy compositions and methods of use Dual recombinant gene therapy compositions and methods of use

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61P 9/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2412847

The present invention relates to novel compositions and methods for the treatment of cardiovascular disease. More particularly, the invention relates to gene therapy compositions comprising at least two transgenes encoding angiogenic proteins or peptides. In one aspect the two transgenes are provided in a single gene delivery vector. Alternatively, the composition comprises at least two vectors, each vector comprising a transgene encoding a different angiogenic protein or peptide. The invention also relates to methods of treating cardiovascular disease using the gene therapy compositions; kits for gene delivery; and pharmaceutical compositions.

La présente invention concerne de nouvelles compositions et méthodes destinées au traitement des maladies cardiovasculaires. L'invention concerne, en particulier, des compositions de thérapie génique renfermant au moins deux transgènes codant des protéines ou peptides angiogéniques. Selon un aspect de l'invention, ces deux transgènes sont véhiculés par seul vecteur d'apport de gènes. Dans un autre mode de réalisation, la composition renferme au moins deux vecteurs, chaque vecteur comprenant un transgène codant une protéine ou un peptide angiogénique différent. L'invention concerne également des méthodes de traitement des maladies cardiovasculaires utilisant lesdites compositions de thérapie génique ; des kits d'apport de gènes ; et des compositions pharmaceutiques.

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