Dual-release compositions of a cyclooxygenase-2-inhibitor

A - Human Necessities – 61 – K

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Details

A61K 31/42 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01) A61K 31/135 (2006.01) A61K 31/341 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2394232

Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility, for example celecoxib, in an immediate-release fraction and a controlled-release, slow-release, programmed-release, timed-release, pulse- release, sustained-release or extended-release fraction. The compositions are useful in treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders.

Cette invention se rapporte à des compositions pharmaceutiques comprenant une ou plusieurs formes galéniques administrées par voie orale, contenant chacune un médicament inhibiteur de cyclo-oxygénase-2 sélectif à faible solubilité dans l'eau, par exemple célécoxib, dans une fraction à libération immédiate et une fraction à libération régulée, à libération lente, à libération programmée, à libération retard, à libération par impulsions ou à libération soutenue. Ces compositions sont utiles dans le traitement ou la prophylaxie des états et des troubles dont le médiateur est la cyclo-oxygénase-2.

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