Dual small molecule inhibitors of cancer and angiogenesis

Details Dual small molecule inhibitors of cancer and angiogenesis Dual small molecule inhibitors of cancer and angiogenesis

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 31/517 (2006.01) C07D 217/24 (2006.01) C07D 221/12 (2006.01) C07D 221/16 (2006.01) C07D 237/30 (2006.01) C07D 239/91 (2006.01) C07D 401/12 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2568622

The present invention provides analogs and derivatives of thalidomide which inhibit cancer and angiogenesis. The present invention further provides compounds which disrupt microtubule polymerization. The present further provides methods of treating cancers comprising mutant p53.

La présente invention fournit des analogues et des dérivés de la thalidomide qui inhibent le cancer et l~angiogenèse. La présente invention fournit en outre des composés qui interrompent la polymérisation des microtubules. La présente invention fournit de plus des méthodes de traitement des cancers comprenant le mutant p53.

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