Dual specific single domain antibodies specific for a ligand...

Details Dual specific single domain antibodies specific for a ligand... Dual specific single domain antibodies specific for a ligand...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/34 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2511910

The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificitiy for a target ligand and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity for a receptor of the target ligand.

L'invention concerne un ligand possédant une double spécificité et comprenant un premier domaine variable d'immunoglobuline présentant une première spécificité de fixation avec un ligand ciblé, ainsi qu'un domaine variable d'immunoglobuline complémentaire ou non complémentaire possédant une deuxième spécificité de fixation avec un récepteur de ce ligand ciblé.

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