Dual specificity antibodies and methods of making and using

Details Dual specificity antibodies and methods of making and using Dual specificity antibodies and methods of making and using

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 37/06 (2006.01) C07K 14/545 (2006.01) C07K 16/24 (2006.01) C12N 15/63 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2411374

Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1.alpha. and IL-1.beta. and neutralize IL-1.alpha. and IL-1.beta. activity in vitroand in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL- 1.alpha. and IL-1.beta.) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1.alpha. and/or IL-1.beta. activity is detrimental.

La présente invention concerne des anticorps à double spécificité pour deux antigènes distincts mais structurellement connexes. Ces anticorps peuvent être notamment des anticorps entièrement humains, des anticorps de recombinaison, ou des anticorps monoclonaux. Les anticorps préférés, qui présentent une spécificité double pour l'IL-1.alpha. et l'IL-1.beta., neutralisent les activités IL-1.alpha. et IL-1.beta. aussi bien in vitro qu'in vivo. Un anticorps selon l'invention peut être un anticorps pris sur toute sa longueur, ou uniquement la partie de cet anticorps se liant à un antigène. L'invention concerne également des procédés de fabrication et des procédés d'utilisation des anticorps de l'invention. Les anticorps ou les parties d'anticorps de l'invention conviennent pour la détection de deux antigènes distincts mais structurellement connexes tels que l'IL-1.alpha. et l'IL-1.beta., et pour l'inhibition de l'activité des antigènes notamment chez un sujet humain soufrant de troubles imputables à l'activité IL-1.alpha. et/ou IL-1.beta..

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