Dual targeting of mir-208 and mir-499 in the treatment of...

Details Dual targeting of mir-208 and mir-499 in the treatment of... Dual targeting of mir-208 and mir-499 in the treatment of...

A - Human Necessities

61

K

A61K 31/7105 (2006.01) A61P 9/00 (2006.01) A61P 21/00 (2006.01) C12N 15/113 (2010.01)

Patent

CA 2751489

The present invention provides a method of treating or preventing cardiac disorders in a subject in need thereof by inhibiting the expression or function of both miR-499 and miR-208 in the heart cells of the subject. In particular, specific protocols for administering inhibitors of the two miRNAs that achieve efficient, long-term suppression are disclosed. In addition, the invention provides a method for treating or preventing musculoskeletal disorders in a subject in need thereof by increasing the expression or activity of both miR-208 and miR-499 in skeletal muscle cells of the subject.

La présente invention porte sur un procédé de traitement ou de prévention de troubles cardiaques chez un sujet en ayant besoin par l'inhibition de l'expression ou de la fonction à la fois de miR-499 et de miR-208 dans les cellules du cur du sujet. En particulier, sont décrits des protocoles spécifiques pour une administration d'inhibiteurs des deux ARNmi qui permettent de parvenir à une suppression de longue durée, efficace. De plus, L'invention porte sur un procédé de traitement ou de prévention de troubles musculo-squelettique chez un sujet en ayant besoin par augmentation de l'expression ou de l'activité à la fois de miR-208 et de miR-499 dans des cellules de muscle squelettique du sujet.

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