C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2562520
The invention is referring to several dual-transfected cell lines expressing human NTCP (Na/taurocholate Cotransporting Protein; SLC10A1) together with human BSEP (Bile Salt Export Pump; ABCB11) or human MRP2 (Multidrug Resistance Protein; ABCC2) suitable as an in vitro tool for pharmaceutical compound profiling particularly as a model for hepatobiliary elimination.
L'invention concerne plusieurs lignées cellulaires doublement transfectées exprimant NTCP (protéine de cotransport Na/taurocholate; SLC10A1) humaine conjointement avec BSEP (pompe d'exportation des sels biliaires; ABCB11) humaine ou MRP2 (protéine de résistance pléiotrope; ABCC2) humaine utiles comme outil in vitro destiné à un profilage de composés pharmaceutiques, notamment comme modèle destiné à l'élimination hépatobiliaire.
Eisenblaetter Tanja
Theis Stefan
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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