Duffy antigen receptor for chemokines and use thereof

A - Human Necessities – 61 – K

Patent

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Details

A61K 8/18 (2006.01) A61Q 13/00 (2006.01) C07H 21/04 (2006.01) C12N 5/18 (2006.01) C12N 15/00 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2585156

The invention relates to Duffy antigen receptor for chemokines and uses thereof. In on embodiment, the invention provides a method for screening for drug candidates that inhibit angiogenesis. The method comprises contacting a molecule with a Duffy antigen receptor for chemokines and determining whether the molecule binds to the Duffy antigen receptor for chemokines. In another embodiment, the invention provides a method for inhibiting tumor growth. In yet another embodiment, the invention provides a method for inhibiting angiogenesis. In a further embodiment, the invention provides a method for promoting tumor necrosis.

L'invention concerne le récepteur de l'antigène Duffy pour les chimiokines et des utilisations de celui-ci. Dans une forme de réalisation, l'invention concerne un procédé de criblage de médicaments candidats qui inhibent l'angiogenèse. Le procédé comporte les étapes consistant à: mettre en contact une molécule avec un récepteur de l'antigène Duffy pour les chimiokines, et déterminer si la molécule se lie audit récepteur. Dans une autre forme de réalisation, l'invention concerne un procédé permettant d'inhiber la croissance tumorale. Dans une autre forme de réalisation encore, l'invention concerne un procédé permettant d'inhiber l'angiogenèse. Dans une autre forme de réalisation enfin, l'invention concerne un procédé favorisant la nécrose tumorale.

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