Duloxetine formulation

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/50 (2006.01) A61K 9/62 (2006.01) A61K 31/381 (2006.01) A61P 13/10 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2691371

A duloxetine pellet formulation comprises: (i) a core including a desired amount of duloxetine; (ii) an enteric coating comprising hydroxypropylmethylcellulose phthalate (HPMCP) as an enteric polymer; and, optionally, (iii) a separating layer located between the core and the enteric coating, the separating layer including polyvinyl alcohol and a low molecular weight hydroxypropylmethylcellulose (HPMC).

L'invention porte sur une formulation de pastilles de duloxétine qui comprend : (i) un noyau renfermant une quantité désirée de duloxétine ; (ii) un enrobage entérique comprenant du phtalate d'hydroxypropylméthylcellulose (HPMCP) comme polymère entérique ; et facultativement (iii) une couche de séparation située entre le cur et l'enrobage entérique et comprenant l'alcool polyvinylique et une hydroxypropylméthylcellulose (HPMC) de faible masse moléculaire.

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