Duocarmycin derivatives as novel cytotoxic compounds and...

Details Duocarmycin derivatives as novel cytotoxic compounds and... Duocarmycin derivatives as novel cytotoxic compounds and...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2627190

The present disclosure provides cytoxic compounds useful as drugs or prodrugs and to drug-cleavable substrate conjugates where the drug and cleavable substrate are optionally linked through a self-immolative linker.

La présente invention concerne des conjugués de substrat clivables médicamenteux qui sont de puissantes cytotoxines. L'invention concerne également des compositions contenant des conjugués de substrat clivables médicamenteux et des procédés de traitement les utilisant.

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