Duplex-forming polynucleotide conjugates

Details Duplex-forming polynucleotide conjugates Duplex-forming polynucleotide conjugates

C - Chemistry, Metallurgy

12

P

C12P 19/34 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2119927

2119927 9306122 PCTABS00021 The invention provides ligand-binding duplexed structures having significantly enhanced stability under physiological conditions. The structures are provided in the form of polynucleotide conjugates capable of adopting a duplexed structure, in which annealable polynucleotide strands are coupled covalently at one or both ends through a chemical linker which establishes a stabilizing bridge between strands. Various applications for the stabilized duplexed structures are described, including therapeutic applications for example in the treatment of AIDS.

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