C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C12N 15/87 (2006.01) A61K 31/713 (2006.01)
Patent
CA 2663601
Provided herein are duplex oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene without the aid of a transfection reagent(s). The duplex oligonucleotide complexes of the disclosure include a conjugate moiety that facilitates delivery to a cell, tissue or organism.
La présente invention concerne des complexes d'oligonucléotides bicaténaires qui peuvent être administrés à une cellule, un tissu ou un organisme afin d'empêcher un gène cible de s'exprimer et ce, sans utiliser de réactifs de transfection. Les complexes d'oligonucléotides bicaténaires de la présente invention renferment un fragment de conjugué qui facilite leur administration à une cellule, un tissu ou un organisme.
Anderson Emily
Kaiser Rob
Khvorova Anastasia
Leake Devin
Yamada Christina
Dharmacon Inc.
Robic
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