Dynamic organ function monitoring agents

Details Dynamic organ function monitoring agents Dynamic organ function monitoring agents

A - Human Necessities

61

K

A61K 51/00 (2006.01) A61M 36/14 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/60 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2425718

Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible regionof light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.

L'invention concerne des dérivés de benzoindole et d'indole fortement hydrophiles qui absorbent la lumière et qui sont fluorescents dans la zone visible de la lumière. Ces composés sont utiles dans le contrôle des fonctions physiologique et organique. Plus précisément, les molécules selon l'invention sont utiles dans le diagnostic optique de maladies cardiaques et rénales, et dans l'estimation de la volémie in vivo.

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