Dynamic pixel scanning for use with maldi-ms

G - Physics – 01 – N

Patent

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G01N 30/72 (2006.01) H01J 49/26 (2006.01)

Patent

CA 2655612

A method for dynamic pixel mass spectrometric imaging, or dynamic pixel imaging is disclosed. The method includes striking a sample to be scanned with a laser beam so that the laser beam releases analytes from the sample. The laser beam and the sample are then displaced relative to one another so that the laser beam substantially continuously traces a predefined path on the sample to release analytes from the sample along the predefined path. A mass analysis of the released analytes is performed.

L'invention concerne un procédé pour une imagerie spectrométrique de masse de pixels dynamiques, ou une imagerie de pixels dynamiques. Le procédé consiste à frapper un échantillon devant être balayé avec un faisceau laser, de telle sorte que le faisceau laser libère des analytes provenant de l'échantillon. Le faisceau laser et l'échantillon sont ensuite déplacés l'un par rapport à l'autre, de telle sorte que le faisceau laser trace de manière sensiblement continue un trajet prédéfini sur l'échantillon pour libérer des analytes de l'échantillon le long dudit trajet prédéfini. Une analyse de masse des analytes libérés est réalisée.

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