Dynemicin analogs: syntheses, methods of preparation and use

Details Dynemicin analogs: syntheses, methods of preparation and use Dynemicin analogs: syntheses, methods of preparation and use

C - Chemistry, Metallurgy

07

D

C07D 491/08 (2006.01) A61K 31/395 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) A61K 31/70 (2006.01) C07D 491/044 (2006.01) C07D 498/08 (2006.01) C07H 15/26 (2006.01) C07H 17/00 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2088499

2088499 9202522 PCTABS00010 A fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting properties. Chimeric compounds having the fused ring system compound as an aglycone bonded to (i) a sugar moiety as the oligosaccharide portion or (ii) a monoclonal antibody or antibody combining site portion thereof that immunoreacts with target tumor cells are also disclosed. Compositions containing a compound or a chimer are disclosed, as are methods of preparing a compound.

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