Dynorphin amide analogs

C - Chemistry – Metallurgy – 07 – K

Patent

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530/7.06

C07K 7/06 (2006.01) C07K 14/665 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1241645

DYNORPHINE AMIDE ANALOGS Abstract of the Disclosure Dynorphin(1-13) has been previously reported to antagonize the analgesia induced by narcotics in naive hosts. Novel compounds are provided which differ from dynorphin(1-13) by neither potentiating nor antagonizing narcotics, such as morphine, in naive animals. In tolerant hosts the new compounds potentiate narcotic or peptide induced analgesia, and in addition are less susceptible to degradation than dynorphin(1-13). Particularly preferred of the new compounds are polypeptides having ten amino acids with nitrogen containing moieties at both termini.

428530

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