Dyrks as modifiers of the apc and axin pathways and methods...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2513668

Human DYRK genes are identified as modulators of the APC and Axin pathways, and thus are therapeutic targets for disorders associated with defective APC and Axin function. Methods for identifying modulators of APC and Axin, comprising screening for agents that modulate the activity of DYRK are provided.

Les gènes DYRK humains sont identifiés comme étant des modulateurs des voies d'APC et d'Axin, et ils sont par conséquent des cibles thérapeutiques pour des troubles associés à une fonction APC et Axin défectueuse. Sont présentés des procédés d'identification de modulateurs d'APC et d'Axin consistant à cribler des agents modulant l'activité de DYRK.

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