E-homo-eburnane derivatives and a process for preparing same

Details E-homo-eburnane derivatives and a process for preparing same E-homo-eburnane derivatives and a process for preparing same

C - Chemistry, Metallurgy

07

D

260/241.1

C07D 471/04 (2006.01) C07D 471/22 (2006.01)

Patent

CA 1192189

E-homo-eburnane derivatives process for their preparation, and pharmaceutical compositions containing these compounds A b s t r a c t The invention relates to racemic or optically active E-homo-eburnane derivatives of the formula /I/, Image /I/ wherein R1 and R2 independently represent an alkyl group having 1 to 6 carbon atoms, and acid addition salts thereof. The new compounds are pharmaceutically active, for example their certain representatives, in particular from the cis-series, show antidepressive activity, while others, especially the compounds of the trans-series, are potent anthypoxial agents. The compounds of the formula /I/ and pharmaceutically acceptable acid addition salts thereof can therefore be employed as active ingredients of pharmaceutical compositions.

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