Early diagnosis of conformational diseases

Details Early diagnosis of conformational diseases Early diagnosis of conformational diseases

G - Physics

01

N

G01N 33/68 (2006.01)

Patent

CA 2413078

A method for the diagnosis or detection of conformational diseases by assaying for a marker (the pathogenic conformer) of such diseases in a sample is described, which method comprises a cyclic amplification system to increase the levels of the pathogenic conformer which causes such diseases. In particular, such transmissible conformational diseases may be prion encephalopathies. Assays, diagnostic kits and apparatus based on such methods are also disclosed.

L'invention concerne un procédé de diagnostic ou de détection de maladies conformationnelles grâce aux dosages biologiques d'un marqueur (le conformère pathogène) de ces maladies dans un échantillon. Ce procédé comporte un système d'amplification cyclique permettant d'augmenter les niveaux du conformère pathogène qui provoque ces maladies. L'invention concerne en particulier les maladies conformationnelles telles que les encéphalopathies du prion. L'invention concerne également des dosages biologiques, des assemblages de diagnostic et un appareil conçus à partir de ces procédés.

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